Phenylsulfonyl furoxan
WebAug 10, 2016 · It is found that PSMC2 was upregulated in ovarian cancer tissues, associated with tumor grade and could probably predict poor prognosis and may promote the development of ovarian cancer through CCND1, which may predictpoor prognosis of ovariancancer patients. 2 PDF WebMar 15, 2024 · Numerous investigations have shown that furoxans are widely used for the NO donor-based therapy to fight cancer. In response to thiol-containing molecules, furoxans can generate high levels of NO, which react with superoxide to produce peroxinitrite or ONOO − leading to p53 increase, thus exerting potent anticancer activity [ 27, 36, 37 ].
Phenylsulfonyl furoxan
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WebJan 1, 2024 · Furoxans are an important class of NO donors, which can release high levels of NO in vitro [8]. 3,4-Bis (phenylsulfonyl)-1,2,5-oxadiazole 2-oxide (phenylsulfonylfuroxan), as a NO donor, was widely used in the design of anti-cancer and cancer sensitization agents. WebMay 13, 2013 · Abstract. A series of hybrids ( 12a – k) from (phenylsulfonyl)furoxan and anilinopyrimidine were synthesized and biologically evaluated as epidermal growth factor …
WebMar 1, 2024 · In the present study, thirty β-carboline- (phenylsulfonyl)furoxan hybrids (11a−j, 12a−j and 13a−j) were designed and synthesized through esterification and amidation reaction strategy, and their... WebMay 15, 2024 · In the present study, thirty β-carboline- (phenylsulfonyl)furoxan hybrids (11a-j, 12a-j and 13a-j) were designed and synthesized through esterification and amidation …
WebJul 10, 2024 · Furoxan, 1,2,5-oxadiazole N -oxide, is an important scaffold of many compounds that show typical NO-donor properties in mammals, some furoxan derivatives being known as NO-donating pro-drugs [ 23 – 27 ]. WebAward-winning innovative lecturer in Medicinal Chemistry at the University of Nottingham. Passionate about inspiring students for careers in the …
WebJun 23, 2024 · solubility of seco-coumarin and furoxan hybrid 3 with hydrazide side chain was 8.2 μ g/mL in 820-fold higher than 0.01 μ g/mL of the lead 2 , which suggested that hydrazine is a favorable group
WebPhenol 10 was then coupled to 3,4-bis (phenylsulfonyl)furoxan ( 2) in a subsequent step using NaOH and 2-MeTHF to give the desired compound 12a in low yield. Based on this result, we decided to explore derivative 12a synthesis using another route (route B, Scheme 2) by reversing the steps of route A ( Scheme 2 ). extremity coildocument that can be shared and editedWebMay 13, 2013 · A series of hybrids ( 12a – k) from (phenylsulfonyl)furoxan and anilinopyrimidine were synthesized and biologically evaluated as epidermal growth factor receptor (EGFR) inhibitors for intervention of non-small-cell lung cancer (NSCLC). document the abuse.comWebA series of novel conjugates of podophyllotoxin and norcantharidin was designed using association strategy, and synthesized by coupling 4 ′-demethylepipodophyllotoxin with N-amino acid norcantharimides, and their cytotoxicitiy was evaluated against four human tumor cell lines (A-549, HepG2, HeLa and HCT-8) and normal human diploid fibroblast line … extremity comicWeb4-Methyl-3-(phenylsulfonyl)furoxan C9H8N2O4S CID 193841 - structure, chemical names, physical and chemical properties, classification, patents, literature ... document that allows you to driveWebTo develop multifunctional drugs, a series of celastrol/NO donor hybrids were designed, synthesized and evaluated. The detection of NO release amounts showed that the more NO of these hybrids released, the more tumor cells were inhibited. 11b, which released the highest level of NO in vitro, exhibited superior potency (IC 50 = 0.48 ± 0.06 μM) compared … extremity coldnessWebThe incorporation of furoxan and sydnonimine ring systems into amino acid side chains is demonstrated with the preparation of four novel amino acids which carry these nitric … document that created the judicial branch