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Phenotypically modulated

WebFeb 11, 2024 · Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female … WebNov 8, 2024 · The root system architecture (RSA) of plants is highly dependent on the surrounding nutrient environment. The uptake of essential nutrients triggers various signaling cascades and fluctuations in plant hormones to elicit physical changes in RSA. These pathways may involve signaling components known as small signaling peptides …

Potential Contribution of Phenotypically Modulated …

WebAug 1, 2024 · In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate, proliferate and migrate in a process known as phenotypic modulation. However, the phenotype of... WebNov 11, 2024 · In-depth single-cell RNA sequencing demonstrates that SMC-Has3 deletion driven expansion of phenotypically modulated SMC drives increases in acute-phase response gene expression. Blocking the important HA binding receptor, cluster of differentiation-44 (CD44), recapitulates the enhanced acute-phase response and … ginger coiffeur winterthur https://procisodigital.com

KLF4-dependent phenotypic modulation of smooth …

WebJan 13, 2013 · We identified large numbers of phenotypically modulated SMCs in lesions that showed no detectible expression of MYH11 ( Fig. 4c) or ACTA2 ( Fig. 4d) and were identifiable as being of SMC origin... WebOct 7, 2024 · To form the FC, SMC undergo phenotypic modulation in response to atherogenic stimuli and migrate from the media into atherosclerotic lesions. 5–7 Recent lineage tracing studies in mice revealed that SMC can be beneficial or detrimental in atherosclerotic lesions, depending on the specific SMC phenotypic transitions. 7–13 For … WebJun 26, 2008 · Animal Model KLF5 is a transcription factor for Smemb/nonmuscle myosin heavy chain B, which is a molecular marker of phenotypically modulated smooth muscle cells. Normally, KLF5 is abundantly expressed in developing blood vessels, but is downregulated in adult vessels. ginger cold tolerance

Sp1-dependent activation of KLF4 is required for PDGF-BB-induce…

Category:Atheroprotective roles of smooth muscle cell phenotypic …

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Phenotypically modulated

Entry - *602903 - KRUPPEL-LIKE FACTOR 5; KLF5 - OMIM

WebAug 31, 2012 · Previous studies have shown that SMC phenotype is actively regulated via transduction of growth factor-mediated and biomechanical signals to the nucleus … WebMay 23, 2024 · Methods: To perform an unbiased and systematic analysis of the molecular regulatory mechanism of phenotypic switching of SMCs during AS in mice, we searched …

Phenotypically modulated

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WebSep 15, 2024 · these SMC progenies have been previously lumped together as phenotypically modulated SMC, advances in single cell RNA profiling has demonstrated the presence of subsets of these cells with distinct transcriptomes and cell fates. For example, medial SMC have been shown to give WebThis increase in the number of phenotypically modulated perivascular cells was specific to pre-metastatic lung tissue, in that a similar expansion of perivascular cells was not seen in other...

WebMay 18, 2015 · Shown are phenotypically modulated SMCs (YFP + ACTA2 − cells highlighted in the white rectangle, b ), macrophage-like SMCs (YFP + ACTA2 − LGALS3 +, … WebJun 1, 2012 · Phenotypically modulated SMCs are characterized by a decreased expression of SMC-specific proteins and show a high degree of proliferation and the ability to …

WebFeb 11, 2024 · Phenotypically modulated smooth muscle cells (SMCs) contribute to atherosclerosis in women. How these phenotypically modulated SMCs shape female versus male plaques is unknown. Here, we show sex-stratified gene regulatory networks (GRNs) from human carotid atherosclerotic tissue. WebJul 29, 2024 · Phenotypically modulated SMCs have previously been noted to express markers associated with myofibroblasts (Acta2), mesenchymal stem cells (Sca1) and …

WebApr 1, 2009 · The phenotypic modulation of SMCs plays an important role in normal vascular development as well as the progression of vascular diseases such as atherosclerosis and …

WebNational Center for Biotechnology Information ginger coin cookiesWebKLF4 Dependent Phenotypic Modulation of SMCs Plays a Key Role in Atherosclerotic Plaque Pathogenesis - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. ginger collins north yarmouth meWebOct 22, 2024 · To determine whether the dysfunction of the LXRα-ABCA1 axis is common in phenotypically modulated VSMCs, we performed the proteomic analysis of the contractile and synthetic VSMCs and showed that... full grown silkieWebJan 23, 2009 · An accumulation of these phenotypically modulated SMCs within the diseased vessel contributes to plaque formation and the consequent narrowing of the vascular lumen. Our laboratory has had a long-standing interest in unraveling the molecular mechanisms that contribute to the phenotypic modulation of SMCs to prevent or reduce … ginger collins arrestWebSingle cell RNA sequencing (scRNA-Seq) identified phenotypically modulated SMCs (mSMCs) characterized by upregulation of macrophage, fibroblast, and chrondrocyte markers that appear with atherosclerotic plaque formation in Apoe-/- mice aortas. This transition is dependent on Kruppel-like factor 4 (Klf4). ginger cold hardinessWebFeb 25, 2015 · Assessment of phenotypically modulated smooth muscle cells SMCs in vascular lesions were immunophenotyped using two anti-SMC myosin heavy chain markers (SM1 and SM2) and three anti-actin markers (αSMA, HHF35, and CGA7). ginger coleslawWebApr 25, 2024 · During aneurysm formation, smooth muscle cells undergo a process known as phenotypic modulation. Although this process has been well-studied, the possible role … ginger cold tea