Fat10 in cancer

Author: mjhu

August undefined, 2024

WebNov 1, 2024 · Since these special mechanisms regulated by FAT10 are involved in many significant cellular pathways promoting the progression of cancer, emerging evidence … WebJan 1, 2024 · The results of the current study indicate that there is a correlation between FAT10 and HK2 in the progression of bladder cancer. In addition, we identified a new pathway that may be involved in the regulation of HK2. These findings implicate dysfunction of the FAT10, EGFR/AKT, and HK2 regulatory circuit in the progression of bladder cancer.

Silibinin down-regulates FAT10 and modulate TNF-α/IFN-γ …

WebThe results of our FAT10 survival analysis for cancer types of interest show that FAT10 expression was increased in SKCM and correlated with a better survival rate in … WebFAT10 is involved in cancer development, however, its biological role is still unclear, as well as its biochemical and cellular regulation. To identify pathways underlying FAT10 expression in the context of pro-inflammatory stimulation, which characterizes the cancerous environment, we implemented a phenotypic transcriptional reporter screen ... seoul national university biology

Frontiers Ubiquitin-Like Protein UBD Promotes Cell Proliferation …

WebAug 30, 2024 · To evaluate the expression of FAT10 among various digestive system tumors, FAT10 expression was first evaluated in digestive cancer samples. Based on an array containing 4 digestive cancer samples from patients and corresponding noncancerous tissues for immunohistochemical staining, it was found that FAT10 expression was up … WebJul 1, 2016 · FAT10 expression levels are highly upregulated in many different cancer cell types such as colon cancer, glioma, osteosarcoma, hepatocellular carcinoma (HCC), … WebNational Center for Biotechnology Information seoul national university asia center

The ubiquitin-like modifier FAT10 in cancer development

WebSep 14, 2014 · The FAT10 gene is overexpressed in various cancers, such as gastrointestinal cancer, HCC, pancreatic ductal adenocarcinoma, and human glioma . In the liver, FAT10 overexpression is an epigenetic marker for liver neoplasia ( 13 ). WebOct 1, 2016 · FAT10 thereby regulates pathways involved in cancer development such as the NF-κB- or Wnt-signaling. Moreover, FAT10 directly interacts with and influences downstream targets such as MAD2, p53 or β-catenin, leading to enhanced survival, proliferation, invasion and metastasis formation of cancer cells but also of non-malignant … the sword dramaWebFAT10 thereby regulates pathways involved in cancer development such as the NF-κB- or Wnt-signaling. Moreover, FAT10 directly interacts with and influences downstream targets such as MAD2, p53 or β-catenin, leading to enhanced survival, proliferation, invasion and metastasis formation of cancer cells but also of non-malignant cells. seoul national museum of art

"WebFAT10 is associated with the malignancy and drug resistance of non-small cell lung cancer Feng Xue,1,2,* Lin Zhu,3,* Qing-wei Meng,1 Liyan Wang,2 Xue-song Chen,1 Yan-bin Zhao,1 Ying Xing,1 Xiao-yun Wang,1 Li Cai1 1The Fourth Department of Medical Oncology, Harbin Medical University Cancer Hospital, 2Department of Medical Oncology, … " - Fat10 in cancer

Fat10 in cancer

FAT10 promotes the invasion and migration of breast cancer …

WebAug 14, 2016 · To further investigate whether FAT10 regulates eEF1A1 expression in other cancer cells, we first examined the levels of FAT10 and eEF1A1 by Western blot analysis in a variety of cancer cell lines (i.e., HCC, breast cancer, colorectal cancer, pancreatic cancer, and cervical cancer). WebNov 30, 2024 · In addition, FAT10 may be a novel cancer biomarker that contributes to proliferation, invasion, and metastasis in a broad spectrum of cancer cells, including …

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WebOct 28, 2016 · Moreover, FAT10 expression was highly upregulated in many different cancer types, such as colon and breast cancer, where it enhanced cancer cell migration, invasion, and metastasis formation [63]. ...

WebUbiquitin D Rabbit Monoclonal Antibody. FAT10, also designated Ubiquitin D or Diubiquitin, is a 165 amino acid protein encoded in the major histocompatibility complex (MHC) that consists of two domains which share significant homology with ubiquitin. Each domain contains two cysteines, along with a free C-terminal diglycine motif required for ... WebApr 1, 2024 · In addition, FAT10 may be a novel cancer biomarker that contributes to proliferation, invasion, and metastasis in a broad spectrum of cancer cells, including hepatocellular carcinoma (HCC), glioma, and gastric carcinoma. These findings imply that FAT10 will be a candidate target during treatment of cardiovascular conditions due to its ...

WebFAT10 is associated with the malignancy and drug resistance of non-small cell lung cancer Feng Xue,1,2,* Lin Zhu,3,* Qing-wei Meng,1 Liyan Wang,2 Xue-song Chen,1 Yan-bin … WebNov 24, 2014 · FAT10 (HLA-F-adjacent transcript 10) is a ubiquitin-like modifier that is commonly overexpressed in various tumors. It was found to play a role in mitotic regulation through its interaction with mitotic arrest …

WebConclusion: UBD upregulation was linked to better clinical prognosis, favorable pathological features, and good treatment response in rectal cancer patients undergoing CCRT. These results suggest UBD is a biomarker for rectal cancer. Keywords: ubiquitin D, UBD, FAT10, rectal cancer, concurrent chemoradiotherapy.

WebFAT10 thereby regulates pathways involved in cancer development such as the NF-κB- or Wnt-signaling. Moreover, FAT10 directly interacts with and influences downstream … the sword drawing art of iaido is based onWebSep 9, 2024 · The tumor suppressor protein p53 is a FAT10 substrate and a double-negative regulation of FAT10 and p53 was observed to be critical in the control of tumorigenesis, which is in line with the ... seoul namsan towerWebAn overexpressed FAT10 stimulates nuclear factor-kappa β, activates the inflammatory pathways, and induces the proliferation of cancer. The FAT10 protein interacts with the mitotic arrest ... seoul national university bundangWebJun 29, 2015 · Our previous study revealed that FAT10 expression is induced by TNF-α through the NF-κB pathway in cancer cells (including HCT116 and HepG2) making them resistant to TNF-α-induced apoptosis and facilitating CIN (Ren et al., 2011). Silibinin is a flavonoid isolated from milk thistle seeds with anti-cancer effects against a variety of … the sword eagle riverWebMay 25, 2024 · To evaluate the expression of FAT10 among various digestive system tumors, FAT10 expression was first evaluated in digestive cancer samples. Based on an … the sword dynasty wikiWebNov 1, 2024 · FAT10 is an important target for research and therapeutics for cancer and inflammation implicating a potential role of FAT10 on inflammation induced tumorigenesis. FAT10 overexpression is associated with the regulation of several inflammation driving pathways in cancer development, such as the AKT pathway, the Wnt pathway, and the … the sword edged blondeWebNov 24, 2014 · FAT10 (HLA-F-adjacent transcript 10) is a ubiquitin-like modifier that is commonly overexpressed in various tumors. It was found to play a role in mitotic regulation through its interaction with mitotic arrest-deficient 2 (MAD2). Overexpression of FAT10 promotes tumor growth and malignancy. Here, we identified the MAD2-binding interface … seoul national university business school