Chimeric orthopoxvirus
WebOct 9, 2024 · The conditionally replication-competent chimeric orthopoxvirus (CF17) successfully exhibited the ability to suppress tumor growth and increase survival in preclinical peritoneal ovarian metastases … WebJun 17, 2024 · A novel oncolytic chimeric orthopoxvirus encoding luciferase enables real-time view of colorectal cancer cell infection. Mol Ther Oncolytics. 2024;9:13–21. PubMed PubMed Central Google Scholar
Chimeric orthopoxvirus
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WebSep 25, 2024 · Anthony K. Park et.al utilized an oncolytic chimeric orthopoxvirus carrying a CD19t-encoding gene to infect solid tumor cells including those of pancreatic cancer, prostate cancer, and breast cancer. They demonstrated that OVs can effectively deliver the CD19-CAR target to solid tumors and upregulate the expression of CD19t on the surface … WebApr 26, 2024 · Detailed Description: CF33-hNIS, a novel chimeric orthopoxvirus, will be administered as a monotherapy or in combination with pembrolizumab to assess the …
Weborthopoxvirus vectors, genes and products thereof专利检索，orthopoxvirus vectors, genes and products thereof属于···痘苗病毒或天花病毒专利检索，找专利汇即可免费查询专利，···痘苗病毒或天花病毒专利汇是一家知识产权数据服务商，提供专利分析，专利查询，专利检索等数据服务功能。 WebAug 15, 2024 · Introduction and Objective: CF33-hNIS is a novel, chimeric orthopoxvirus with robust anti-tumor activity at relatively low titers and with a low multiple of infectivity (MOI) in a variety of pre-clinical models. This is a Phase 1, open-label, dose escalation study in adult patients with selected advanced or metastatic solid tumors to evaluate the safety …
WebOrthopoxvirus is a genus of viruses in the family Poxviridae and subfamily Chordopoxvirinae.Vertebrates, including mammals and humans, and arthropods serve as natural hosts. There are 12 species in this genus. … WebCF33-hNIS-antiPDL1, a chimeric orthopoxvirus expressing the human sodium iodide symporter (hNIS) and anti-human programmed death-ligand 1 antibody, has demonstrated robust preclinical activity ...
WebScientific Abstract: Oncolytic virotherapy represents a promising approach for treating recurrent and/or drug-resistant ovarian cancer. However, its successful application in the …
WebApr 26, 2024 · Novel chimeric orthopoxvirus isolates CF33 and CF17 show superior cancer cell killing capability compared to the parental individual wild-type virus strains. Fifty-four solid cancer cell lines in ... daltile color wheel wall tiledaltile commerce way woburn maWebApr 28, 2024 · One hundred chimeric orthopoxvirus plaques were picked from CV-1 cells infected with the chimeric orthopoxvirus pool. These 100 plaques were further plaque purified two more times in CV-1 cells to … daltile color wheel subway tileWebJun 29, 2024 · One hundred chimeric orthopoxvirus plaques were picked from CV-1 cells infected with the chimeric orthopoxvirus pool. These 100 plaques were further plaque purified two more times in CV-1 cells to yield 100 clonally purified individual chimeric virus isolates, which, together with the parental viruses, were subjected to high-throughput ... bird city kansas to colorado distanceWebFeb 1, 2024 · CF33-hNIS-antiPDL1, a chimeric orthopoxvirus expressing the human sodium iodide symporter (hNIS) and anti-human programmed death-ligand 1 antibody, has demonstrated robust preclinical activity ... bird city ks clinicWebFeb 4, 2024 · CF33-hNIS-antiPDL1 is a genetically engineered chimeric orthopoxvirus, CF33, armed with the human Sodium Iodide Symporter (hNIS) and anti-PD-L1 antibody (anti-PD-L1). The in vitro cytotoxic ability of this virus against five PDAC cell lines was tested at various doses (multiplicity of infection (MOI) = 0.01, 0.1, 1, 10). Production and … bird city ks cafeWebJun 2, 2024 · CF33-hNIS-anti-PD-L1 (CHECKvacc) is a novel chimeric orthopoxvirus with robust anti-cancer activity in TNBC xenografts. Cells infected with CHECKvacc were shown to express functional human sodium-iodide symporter (hNIS) and anti-PD-L1 proteins. hNIS gene transfer allows tracking of virus by 99mTc single-photon emission computed … bird city kansas county